ACROSS Study: APMEN health Care facility & community assessment to determine populations at Risk Of malaria and primaquine-induced haemolysiS

This study is a community and facility assessment to determine populations at risk of malaria and primaquine induced haemolysis.

The primary objectives of the study are to:

Quantify the microscopic and sub-microscopic prevalence of malaria across Asia;
Determine the prevalence and spectrum of activity of G6PD deficiency in patients with and without malaria across Asia.

The secondary objectives are to:

Evaluate novel qualitative and quantitative diagnostics for the diagnosis of G6PD deficiency;
Evaluate performance of currently used malaria RDTs;
Evaluate ultra-sensitive diagnostics for the diagnosis of malaria;
Identify utility of serological or other survey tools for targeting interventions, and appropriate ways to use them;
Evaluate the perceptions and utility of novel diagnostics in healthcare providers;
Determine the local G6PD and CYP2D6 genotypes present in the local population;
Determine the local prevalence of anaemia;
Quantify prevalence of parasite polymorphisms associated with antimalarial drug resistance;
Assess community understanding of P. vivax infection and radical cure;
Assess community perceptions of P. vivax infection and the concept of radical cure;
Assess health seeking behaviour for P. vivax malaria at community level;
Assess acceptability of G6PD testing among health system stakeholders, health facility staff and local communities;
Review prescription behaviour for radical cure among health facility staff;
Assess adherence to radical cure prescription at health facility level and adherence to radical cure treatment at community level.

PVIVAX