An Open Label Randomized Comparative Study to Assess the Efficacy and Tolerability of Eurartesim® Versus Chloroquine and Nonrelapse Therapy With Primaquine for Uncomplicated Plasmodium Vivax Monoinfection Malaria
A comparative, randomized open study to evaluate effectiveness and tolerability of blood schizonticide treatments.
The aim of this clinical trial is to demonstrate the superiority of the parasitological response on day 42 of dihydroartemisinin plus piperaquine (DHA-PQP or Eurartesim®) versus chloroquine, and to evaluate the proportion of failures up to day 180, considering different days of introduction of primaquine at a dose of 0.50 mg/kg/day for 14 days.
The trial will be undertaken in the Amazonas State (Western Brazilian Amazon), in Manaus, at Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. It is a prospective, open-label, 4-arm, randomized and comparison trial. The Principal Investigator is Wuelton Monterio.
For more information visit: https://clinicaltrials.gov/ct2/show/NCT03208907