Recursos de Plasmodium vivax

This primer provides an overview of available treatment options for vivax radical cure.

The study aimed to assess the feasibility of implementing a new treatment protocol for Plasmodium vivax malaria in Brazil, incorporating point-of-care quantitative testing for glucose-6-phosphate dehydrogenase (G6PD) deficiency followed by appropriate medication. Conducted across 43 health facilities in Manaus and Porto Velho, the study enrolled 6075 patients presenting with P. vivax mono-infection or mixed infection. The study supports the operational feasibility of implementing quantitative G6PD testing before tafenoquine administration, indicating its potential for deployment throughout the Brazilian health system to aid in malaria elimination efforts.

Supplementary materials to “Optimizing test and treat options for vivax malaria: an option assessment toolkit (OAT) for Asia Pacific National Malaria Control Programs”.

El objetivo de este estudio era evaluar la seguridad de un tratamiento de primaquina de corta duración a dosis altas (dosis total de 7 mg/kg durante 7 días) en pacientes con un 70% o más de actividad de G6PD y malaria por P. falciparum. El ensayo también pretendía evaluar la eficacia de la cura radical universal para reducir el riesgo de episodios posteriores de P vivax en comparación con el tratamiento estándar actual para el P falciparum, que implica el tratamiento esquizontocida de los parásitos en estadio sanguíneo más una dosis única de primaquina para eliminar los estadios sexuales del parásito.

In Colombia, a pilot implementation of G6PD testing has started in four health facilities in Quibdó (Chocó). This initiative builds upon the positive outcomes of the Pilot Educational Program (PEP) on G6PD testing in the country. The pilot implementation applies the tested methodology and materials from the PEP in real-world settings, aiming to provide evidence to the Ministry of Health on its use in Plasmodium vivax case management. Lina Zuluaga, the Coordinator from the University of Antioquia, explained the significance of the program and the pivotal role played by the pilot implementation in paving the way for the introduction of new malaria treatment schemes.