Evaluation of treatment for uncomplicated malaria in endemic areas of the Peruvian Amazon

This study will evaluate the therapeutic effectiveness of the treatment for uncomplicated malaria indicated by the Ministry of Health of Peru, through a prospective cohort in malaria-endemic areas in the Peruvian Amazon. People with uncomplicated P. falciparum and / or P. vivax malaria, who have received an indication for antimalarial treatment at the corresponding health facility and who meet the inclusion criteria of the study, will be registered and followed up for 180 days. Based on the results of these evaluations, study participants will be classified as early treatment failure, late clinical failure, late parasitological failure, or adequate clinical and parasitological response, in accordance with current WHO criteria.

Aim:

  • To evaluate the therapeutic effectiveness of treatment for uncomplicated malaria in endemic areas of the Peruvian Amazon.

Primary objectives:

  1. Measure the clinical and parasitological effectiveness of routine treatment for uncomplicated P. vivax malaria;
  2. Measure the clinical and parasitological effectiveness of routine treatment for uncomplicated P. falciparum malaria.

Secondary objectives

  1. Determine the presence of polymorphisms in marker genes for resistance to antimalarial drugs.