G6PD study to test performance of quantitative tests in Phase 1 and then conducting a HF-based phase 2 using the test results to guide treatment in women and children

Aims and objectives

  1. To assess the sensitivity, specificity, positive predictive value, and negative predictive value of new inexpensive and operationally simple G6PD screening tests under field conditions when compared to the gold standard (quantitative assay) and the fluorescent spot test;
  2. To evaluate the operational ease of use and programmatic usefulness of the tests in terms of accurate transcription of the G6PD level and hypothetical treatment algorithm decisions;  
  3. To assess whether the performance of the tests are influenced by malaria infection (i.e. in symptomatic malaria patients compared to non-malaria infected, febrile patients, and healthy community members); 
  4. To assess whether the performance of the tests is influenced by the type of blood used (capillary vs venous blood samples)
  5. To explore a system of G6PD status registration.