False positive tests for syphilis; a study of their incidence in sporozoite-induced vivax malaria.

05 Apr 1947

The disease malaria has been well established as one of the conditions which may produce a positive serologic reaction for syphilis in nonsyphilitic persons. Various investigations, however, have yielded data that varies widely as to the incidence of such false positive reactions. Excellent reviews of these studies have been published by Davis and Beerman.

An opportunity to reinvestigate the problem was afforded us two years ago when the United States Public Health Service initiated experiments concerned with the chemotherapy of sporozoite-induced human malaria. Our primary interest in obtaining specimens of serum from the subjects of these experiments lay in the development of a quantitatively standardized complement fixation test for malaria.