Liver function tests in neurosyphilitic patients with induced vivax malaria of Pacific and Mediterranean origin.

1.1. The results of the bromsulfalein test showed that:1.1.

(a) In 138 patients tested prior to fever therapy, fifteen per cent had abnormal values with only three individuals having 10 per cent or more retention.

(b) During fever therapy, of eighteen patients studied, fifteen, or 83 per cent, had abnormal values with ten ranging between 12 and 40 per cent. Following fever therapy fifteen of these patients had normal values.

(c) Following fever therapy sixty-six of the 138 patients were re-examined, and fifty-eight of them, or 88 per cent, were normal.

2. Cephalin flocculation tests using Wilson and Difco antigens showed that before inoculation and up until the first positive smear the percentage of 3 and 4 plus tests was zero; however, by the twenty-first day it was 100. No tests were performed after termination of fever.

3. Only one of 106 patients on whom galactose tolerance tests were performed prior to malarial therapy had an abnormal value. Following therapy thirty-one of these men were retested, and all had normal values.

4. The intravenous hippuric acid test was performed on twenty-five patients prior to fever therapy, and all results were normal. Twenty-two of these men were retested during fever therapy, and three had abnormal values. On the re-examination of two of them following therapy, one still remained abnormal. An additional ten of the original men were retested following fever therapy and gave normal findings.

5. The icterus index and serum bilirubin concentration were determined on the same sera of thirty-two patients. During the last seven days of fever therapy abnormal values were found in 38 and 17 per cent, respectively, with a rise to 47 and 24 per cent during the first four days of quinacrine treatment and a fall to 15 and 12 per cent in the next three days.

6. The urine urobilinogen test was performed on the same thirty-two patients just mentioned. All tests were normal prior to the first positive smear, but by seven days later 41 per cent were abnormal with a fall to 6 per cent abnormal tests at the end of quinacrine treatment.