Pentaquine (SN-13,276) a new antimalarial effective in reducing the relapse rate of vivax malaria.

Pentaquine, SN-13,276, has been found to be one of the most promising members thus far studied of a series of antimalarial drugs related to pamaquin. It has the property, also possessed by toxic doses of pamaquin (plasmochin), of eradicating vivax infections, accomplishing this with doses which produce only mild reactions in most individuals. This paper describes the therapeutic trials upon which these conclusions are founded.