Studies in human malaria. XXXI. Comparison of primaquine, isopentaquine, SN-3883, and pamaquine as curative agents against Chesson strain vivax malaria.

In Part I of this study six therapeutic regimens employing four different 8-aminoquinoline derivatives were tested under strictly controlled conditions in mosquito-transmitted Chesson strain vivax malaria, experimentally induced in volunteers in a Federal penal institution. Thirty-four men were treated with each regimen. Test drugs were given every 6 hours for 14 days, in combination with quinine sulfate, 250 mg. of base every 6 hours for the same period. 

Full text article: http://www.ajtmh.org/content/journals/10.4269/ajtmh.1953.2.949