The concurrent weekly administration of chloroquine and primaquine for the prevention of Korean vivax malaria.

The standard method used by the United States Armed Forces for the chemoprophylaxis of malaria is as follows. While personnel are in a malarious area 300 mg chloroquine base are administered once a week. Upon leaving the malarious area 600 mg chloroquine base plus 15 mg primaquine base are administered on the first day of departure followed by 15 mg primaquine for the next 13 days. This regimen has been highly successful in the prevention of malaria.a, b However, a better method of malaria chemoprophylaxis is desirable because the present method requires the strict control of all individuals for a period of two weeks after leaving the area of exposure to ensure adherence to schedule. This is particularly difficult administratively when persons are transported by air or return home by sea if the voyage is less than 14 days.

Full text article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2555555/pdf/bullwho00318-01...