Treatment of vivax malaria by pyrimethamine (daraprim) and quinine.
01 Apr 1955
Sir Gordon Covell and his colleagues wrote in 1953: "It is clear that pyrimethamine unaided is not a satisfactory drug for the treatment of vivax malaria in a non-immune subject." The two main reasons for this conclusion is its slowness of clinical response and the high relapse rate.
Full text article: https://militaryhealth.bmj.com/content/101/2/153