PVIVAX

Knowledge sharing for relapsing malaria

PVIVAX Knowledge sharing for relapsing malaria

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  • P. vivax malaria
    • Malaria and P. vivax malaria
    • Symptoms & severity
    • Illness and mortality
    • Populations at risk
      • Pregnant women and children
      • Migratory populations
    • Role in malaria elimination
    • Lifecycle
    • Relapses
    • Vectors
  • Diagnosis & treatment
    • Diagnostic methods
      • Microscopy
      • Rapid diagnostic tests
      • Molecular methods & serology
    • Diagnosing severe vivax malaria
    • Treatment
      • Radical cure
      • Blood stage treatment
      • Liver stage treatment
    • G6PD Deficiency
      • G6PD Global Prevalence
      • G6PD diagnostics
      • Types of G6PD clinical diagnostic tests
  • Regions & countries
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    • South East Asia
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  • In the field
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      • The Partnership for Vivax Elimination (PAVE)
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Map with highlighted countries to indicate where studies are taking place

P. vivax malaria studies:  A database of studies focusing on improving access to radical cure.

View the database

Photo: istock

About the P. vivax information hub. 

Photo: istock

Featured resources

Healthworker and patient in a consultation

Partnership for Vivax Elimination (PAVE) Feasibility Studies and Operational Research

PAVE is conducting feasibility studies and operational research to support Ministries of Health in malaria endemic countries to look at the best way to use different P. vivax relapse treatments and diagnostics at different levels of the healthcare system in support of their elimination goals.
young man and woman sitting on a bench outside health clinic

the Tafenoquine Roll-out STudy (TRuST)

The Brazilian Ministry of Health (MoH) and MMV, are conducting a study to understand the feasibility of providing appropriate radical cure treatment (primaquine - PQ - or tafenoquine – TQ) based on the results of G6PD testing conducted in real-world settings. 
Screenshot of film
14 Dec 2022

The ARCTIC study: optimizing P. vivax radical cure in Thailand

This short film introduces the 'ARCTIC' feasibility study in Thailand. A study looking at the operational feasibility of using quantitative G6PD testing prior to treatment for Plasmodium vivax malaria relapse with tafenoquine or primaquine.

Medicines for Malaria Venture (MMV)
Videos
rice fields landscape with text in front
21 Apr 2023

The APMEN Vivax Working Group: Supporting malaria elimination in Asia-Pacific

This short video explores the role of the APMEN Vivax Working Group in the fight against malaria in the Asia-Pacific region. The APMEN Vivax Working Group is currently hosted and co-chaired by Medicines for Malaria Venture (MMV).

MMV
Videos
1

News

Health worker taking finger prick blood test from child in Brazil

Brazil becomes the first malaria-endemic country to register single-dose tafenoquine for children with relapsing malaria

21 Aug 2023
blood smears in a clinic

WHO call for public consultation on preferred product characteristics (PPCs) on tests for risk of P. vivax relapse

10 Aug 2023
Mother holding young child at home

Brazil becomes the first malaria-endemic country to adopt single-dose tafenoquine and STANDARD G6PD Test for the treatment of relapsing Plasmodium vivax malaria

06 Jun 2023
Screen shot of opening film sequence "From Science to Real Life"

MMV’s film on real-world tafenoquine study wins advocacy award at the 7th annual ISNTD festival

28 Mar 2023
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1

Events

1

Publications

08 May 2023

Assessing the Operational Feasibility of Integrating Point-of-Care G6PD Testing into Plasmodium vivax Malaria Management in Vietnam

Plasmodium vivax cases represent more than 50% of a diminishing malaria case load in Vietnam. Safe and effective radical cure strategies could support malaria elimination by 2030. This study investigated the operational feasibility of introducing point-of-care quantitative glucose-6-phosphate dehydrogenase (G6PD) testing into malaria case management practices. 

Pathogens
Peer-reviewed article
09 Mar 2023

Study protocol for development of an options assessment toolkit (OAT) for national malaria programs in Asia Pacific to determine best combinations of vivax radical cure for their given contexts

This paper outlines the process of OAT development in detail to inform relevant stakeholders and assist other researchers developing similar toolkit/s in other settings for malaria or for other diseases.

PLOS ONE
Peer-reviewed article
05 Mar 2023

Association of G6PD status and haemolytic anaemia in patients receiving anti-malarial agents: a systematic review and meta-analysis

This study aims to analyse the association of G6PDd and anaemia in malaria patients receiving anti-malarial drugs.

Malaria Journal
Peer-reviewed article
06 Dec 2022

The clinical pharmacology of tafenoquine in the radical cure of Plasmodium vivax malaria: An individual patient data meta-analysis

This study analyzes the currently recommended adult dose of tafenoquine and concludes it is insufficient for radical cure in all adults.

eLife
Peer-reviewed article
View all publications

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