PVIVAX

Knowledge sharing for relapsing malaria

PVIVAX Knowledge sharing for relapsing malaria

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  • P. vivax malaria
    • Malaria and P. vivax malaria
    • Symptoms & severity
    • Illness and mortality
    • Populations at risk
      • Pregnant women and children
      • Migratory populations
    • Role in malaria elimination
    • Lifecycle
    • Relapses
    • Vectors
  • Diagnosis & treatment
    • Diagnostic methods
      • Microscopy
      • Rapid diagnostic tests
      • Molecular methods & serology
    • Diagnosing severe vivax malaria
    • Treatment
      • Radical cure
      • Blood stage treatment
      • Liver stage treatment
    • G6PD Deficiency
      • G6PD Global Prevalence
      • G6PD diagnostics
      • Types of G6PD clinical diagnostic tests
  • Regions & countries
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      • The Partnership for Vivax Elimination (PAVE)
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Map with highlighted countries to indicate where studies are taking place

P. vivax malaria studies:  A database of studies focusing on improving access to radical cure.

View the database

Photo: istock

About the P. vivax information hub. 

Photo: istock

Featured resources

Film opening title
12 Dec 2022

From science to real life: Tackling relapsing malaria in the Amazon

A short film highlighting the work of the Tafenoquine Roll-out STudy (TRuST) in Brazil. This study was co-sponsored by the Brazilian Ministry of Health (MoH) and Medicines for Malaria Venture (MMV). Film directed and produced by Hungry Man.

Medicines for Malaria Venture (MMV)
Videos
Healthworker and patient in a consultation

Partnership for Vivax Elimination (PAVE) Feasibility Studies and Operational Research

PAVE is conducting feasibility studies and operational research to support Ministries of Health in malaria endemic countries to look at the best way to use different P. vivax relapse treatments and diagnostics at different levels of the healthcare system in support of their elimination goals.
young man and woman sitting on a bench outside health clinic

the Tafenoquine Roll-out STudy (TRuST)

The Brazilian Ministry of Health (MoH) and MMV, are conducting a study to understand the feasibility of providing appropriate radical cure treatment (primaquine - PQ - or tafenoquine – TQ) based on the results of G6PD testing conducted in real-world settings. 
Screenshot of film
14 Dec 2022

The ARCTIC study: optimizing P. vivax radical cure in Thailand

This short film introduces the 'ARCTIC' feasibility study in Thailand. A study looking at the operational feasibility of using quantitative G6PD testing prior to treatment for Plasmodium vivax malaria relapse with tafenoquine or primaquine.

Medicines for Malaria Venture (MMV)
Videos
1

News

Agents pass along breeding ground in Nossa Vitoria

Regional initiatives and evidence-generation efforts to eliminate P. vivax malaria in Latin America

05 Dec 2022
Single-dose tafenoquine 150mg tablets in palm of hand

Colombia approves single-dose medicine to prevent relapse of P. vivax malaria

03 Oct 2022
healthworkers participating in a training.

Start of ARCTIC, a feasibility study of a new Plasmodium vivax malaria treatment protocol in Thailand

22 Jul 2022
Meeting participants looking at camera

Event Highlights: The Indo-Pacific Regulatory Strengthening Program (RSP) Forum, 2022

09 May 2022
View all news
1

Events

1

Publications

09 Mar 2023

Study protocol for development of an options assessment toolkit (OAT) for national malaria programs in Asia Pacific to determine best combinations of vivax radical cure for their given contexts

This paper outlines the process of OAT development in detail to inform relevant stakeholders and assist other researchers developing similar toolkit/s in other settings for malaria or for other diseases.

PLOS ONE
Peer-reviewed article
05 Mar 2023

Association of G6PD status and haemolytic anaemia in patients receiving anti-malarial agents: a systematic review and meta-analysis

This study aims to analyse the association of G6PDd and anaemia in malaria patients receiving anti-malarial drugs.

Malaria Journal
Peer-reviewed article
06 Dec 2022

The clinical pharmacology of tafenoquine in the radical cure of Plasmodium vivax malaria: An individual patient data meta-analysis

This study analyzes the currently recommended adult dose of tafenoquine and concludes it is insufficient for radical cure in all adults.

eLife
Peer-reviewed article
18 May 2022

Reducing the risk of Plasmodium vivax after falciparum infections in co-endemic areas-a randomized controlled trial (PRIMA)

This is the protocol for a multicentre, health care facility-based, randomized, controlled, open-label trial ongoing in Bangladesh, Indonesia and Ethiopia. The study is evaluating the potential benefit of a universal radical cure for both P. vivax and P. falciparum in different endemic locations. 

Trials
Peer-reviewed article
View all publications

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