PVIVAX

Knowledge sharing for relapsing malaria

PVIVAX Knowledge sharing for relapsing malaria

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  • P. vivax malaria
    • Malaria and P. vivax malaria
    • Symptoms & severity
    • Illness and mortality
    • Populations at risk
      • Pregnant women and children
      • Migratory populations
    • Role in malaria elimination
    • Lifecycle
    • Relapses
    • Vectors
  • Diagnosis & treatment
    • Diagnostic methods
      • Microscopy
      • Rapid diagnostic tests
      • Molecular methods & serology
    • Diagnosing severe vivax malaria
    • Treatment
      • Radical cure
      • Blood stage treatment
      • Liver stage treatment
    • G6PD Deficiency
      • G6PD Global Prevalence
      • G6PD diagnostics
      • Types of G6PD clinical diagnostic tests
  • Regions & countries
    • Africa
      • Ethiopia
    • Eastern Mediterranean
    • South East Asia
      • India
      • Myanmar
      • Nepal
      • Thailand
    • The Americas
      • Brazil
      • Colombia
      • Peru
    • Western Pacific
      • Cambodia
      • Lao People's Democratic Republic
      • Viet Nam
  • Projects
    • The Partnership for Vivax Elimination (PAVE)
      • Training materials
    • PAVE feasibility studies
      • PAVE Peru Feasibility Study
      • The Tafenoquine Roll-out STudy (TRuST)
        • O estudo TRuST
      • SCOPE in Indonesia & PNG
      • The ARCTIC Study
    • Collating evidence of P. vivax in Africa
    • G6PD deficiency data gathering project
  • Tools & training
    • Study database
  • Resources
  • News & events
    • Past events
    • Stories and Videos
  • About us
Map with highlighted countries to indicate where studies are taking place

P. vivax malaria studies:  A database of studies focusing on improving access to radical cure.

View the database

Photo: istock

About the P. vivax information hub. 

Photo: istock

Featured resources

Healthworker and patient in a consultation

Partnership for Vivax Elimination (PAVE) Feasibility Studies and Operational Research

PAVE is conducting feasibility studies and operational research to support Ministries of Health in malaria endemic countries to look at the best way to use different P. vivax relapse treatments and diagnostics at different levels of the healthcare system in support of their elimination goals.
young man and woman sitting on a bench outside health clinic

The Tafenoquine Roll-out STudy (TRuST)

The Brazilian Ministry of Health (MoH) and MMV sponsored study to understand the feasibility of providing appropriate radical cure treatment (primaquine - PQ - or tafenoquine – TQ) based on the results of G6PD testing conducted in real-world settings. 
Screenshot of film
14 Dec 2022

The ARCTIC study: optimizing P. vivax radical cure in Thailand

This short film introduces the 'ARCTIC' feasibility study in Thailand. A study looking at the operational feasibility of using quantitative G6PD testing prior to treatment for Plasmodium vivax malaria relapse with tafenoquine or primaquine.

Medicines for Malaria Venture (MMV)
Videos
rice fields landscape with text in front
21 Apr 2023

The APMEN Vivax Working Group: Supporting malaria elimination in Asia-Pacific

This short video explores the role of the APMEN Vivax Working Group in the fight against malaria in the Asia-Pacific region. The APMEN Vivax Working Group is currently hosted and co-chaired by Medicines for Malaria Venture (MMV).

MMV
Videos
1

News

Health worker taking finger prick blood test from child in Brazil

Brazil becomes the first malaria-endemic country to register single-dose tafenoquine for children with relapsing malaria

21 Aug 2023
blood smears in a clinic

WHO call for public consultation on preferred product characteristics (PPCs) on tests for risk of P. vivax relapse

10 Aug 2023
Mother holding young child at home

Brazil becomes the first malaria-endemic country to adopt single-dose tafenoquine and STANDARD G6PD Test for the treatment of relapsing Plasmodium vivax malaria

06 Jun 2023
Screen shot of opening film sequence "From Science to Real Life"

MMV’s film on real-world tafenoquine study wins advocacy award at the 7th annual ISNTD festival

28 Mar 2023
View all news
1

Events

1

Publications

15 Nov 2023

Primaquine radical cure in patients with Plasmodium falciparum malaria in areas co-endemic for P. falciparum and Plasmodium vivax (PRIMA): a multicentre, open-label, superiority randomised controlled trial

This study aimed to assess the safety of a high-dose short-course primaquine treatment (total dose 7 mg/kg over 7 days) in patients with 70% G6PD activity or greater and P falciparum malaria. The trial also aimed to assess the efficicacy of universal radical cure to reduce the risk of subsequent P vivax episodes compared with the current standard treatment for P falciparum, which entails schizontocidal treatment of blood stage parasites plus a single dose of primaquine to eliminate the sexual parasite stages.
The Lancet
Peer-reviewed article
12 Oct 2023

Clinical performance validation of the STANDARD G6PD test: A multi-country pooled analysis

This research provides an evaluation of the diagnostic performance of one such tool, the STANDARD G6PD Test (SD Biosensor, South Korea), based on extensive data from multiple studies.
PLOS Neglected Tropical Diseases
Peer-reviewed article
22 Sep 2023

Primaquine dose and the risk of haemolysis in patients with uncomplicated Plasmodium vivax malaria: a systematic review and individual patient data meta-analysis

a systematic review and individual patient data meta-analysis to investigate the haematological safety of different primaquine regimens for P. vivax radical cure.
Lancet Infect Dis.
Peer-reviewed article
19 Sep 2023

Case Series of Primaquine-Induced Haemolytic Events in Controlled Trials with G6PD Screening

This study reviews five events of acute haemolytic anaemia following the administration of primaquine in four malaria trials from Indonesia, the Solomon Islands, and Vietnam.
Pathogens
Peer-reviewed article
View all publications

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