14 Feb 2024
Operational feasibility of Plasmodium vivax radical cure with tafenoquine or primaquine following point-of-care, quantitative glucose-6-phosphate dehydrogenase testing in the Brazilian Amazon:a real-life retrospective analysis
The study aimed to assess the feasibility of implementing a new treatment protocol for Plasmodium vivax malaria in Brazil, incorporating point-of-care quantitative testing for glucose-6-phosphate dehydrogenase (G6PD) deficiency followed by appropriate medication. Conducted across 43 health facilities in Manaus and Porto Velho, the study enrolled 6075 patients presenting with P. vivax mono-infection or mixed infection. The study supports the operational feasibility of implementing quantitative G6PD testing before tafenoquine administration, indicating its potential for deployment throughout the Brazilian health system to aid in malaria elimination efforts.