Efficacy and Safety Study of Tafenoquine Co-administered With Dihydroartemisinin-piperaquine (DHA-PQP) for the Radical Cure of Plasmodium Vivax Malaria (INSPECTOR)

Aims and objectives

This study evaluated the efficacy and safety of a single dose of tafenoquine when co-administered with an ACT (i.e. DHA-PQP). This single-center, double-blind, double-dummy, randomized study tested the superiority of DHA-PQP plus TQ against DHA-PQP alone in the prevention of P. vivax malaria relapse at 6 months. The study was conducted in male Indonesian soldiers diagnosed with P. vivax malaria on return from deployment to a malarious region of Indonesia. A PQ plus DHA-PQP comparator arm was included to provide an informal comparison against the standard 14 day treatment for P. vivax malaria in Indonesia.

For more information visit: https://clinicaltrials.gov/ct2/show/NCT02802501