Primary attack of vivax malaria occurring 27 months after infection.

TROPICAL diseases, particularly malaria, have assumed greatly increased diagnostic and therapeutic importance in this country with the return of servicemen from endemic areas.1 2 3 4 Studies of the natural course of relapsing vivax malaria5 , 6 have led to the prediction that cases of this disease, acquired in the Southwest Pacific, would continue to appear for at least three years after the return of the last serviceman.4 5 6 7 In addition, the use of quinacrine (atabrine) for the suppression of malaria has delayed the onset of the primary attack for months, whereas the normal intrinsic incubation period is eight to seventeen days.

Full text article: https://www.nejm.org/doi/full/10.1056/NEJM194809092391105