An evaluation of CI-564 against blood-induced chlorguanide-sensitive and chlorguanide-resistant strains of vivax malaria.

CI-564, a 1:1 mixture of cycloguanil pamoate (CI-501) and 4,4′-diacetylaminodiphenyl sulfone (CI-556), was evaluated as a therapeutic agent against blood-induced infections of the Chesson strain of Plasmodium vivax. With a dose of 5 mg per kg of body weight given intramuscularly, cure was effected in each of two volunteers infected with the chlorguanide-sensitive strain. Clearance of patent parasitemia required 3 to 4 days. In two other volunteers infected with the chlorguanide-resistant strain, the clinical and parasitologic courses were modified, but parasitemia was not cleared after 14 and 28 days.

Full text article: http://www.ajtmh.org/content/journals/10.4269/ajtmh.1967.16.13