Radical cure of relapsing vivax malaria with pentaquine-quinine; a controlled study.

During the recent war, extensive investigations were undertaken in the study and cure of malaria. These studies at first were directed particularly toward finding a substitute for quinine, the supply of which had been cut off by the enemy. It was soon found that quinacrine (atabrine), which had been known since 1930 but not sufficiently appreciated because of improper dosage, was a more satisfactory drug than quinine both as a suppressive and as a treatment of the acute malaria attack.1 Quinacrine, however, has no effect on the relapse rate. Its toxic manifestations are not significant. 

Full text article: https://www.acpjournals.org/doi/10.7326/0003-4819-33-6-1413