Studies in human malaria; the protective and therapeutic action of chloroquine (SN 7618) against St. Elizabeth strain vivax malaria.

Postwar access to the results of German investigations has shown that the compound now known as chloroquine SN7618 had been synthesized and studied under the name resochin by the Germans as early as 1934 (Combined Intelligence Objective Sub-Committee, 1945). Its full antimalarial potentialities were not realised, until after its independent developemnt in the United States in 1944 (Surrey and Hammer, 1946; Elderfield, 1946, Shanon, 1946). The clinical investigation reported in this paper are part of the program for the appraisal of chloroquine planned by the Board of Coordination of General Studies, the general results of which have been summarized by Wiselogle (1946) and Loeb et al (1946).

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