Studies in human malaria; the protective and therapeutic action of quinine sulfate against St. Elizabeth strain vivax malaria.

Although the limitations of quinine as a protective and therapeutic agent were well-recognized, this drug was chosen for the first tests against sporozoite-induced St. Elizabeth strain vivax in the Atlanta program (Coatney, Cooper and Ruhe (1948)) because it was considered a logical standard of reference. It was the principal standard utilized in avian screening (Wiselogle 1946) and its rapid elimination from the body permitted sharper delimitation of its periods of action that was possible with quinacrine, which is retained in the body for long periods. This paper will report tests of quinine-sulphate against mosquito-transmitted St. Elizabeth strain vivax malaria in which (1) the suppressive threshold was established, (2) inactivity against early pre-erythrocytic forms were confirmed, and (3) results of therapy of early and late attacks were confirmed.

Full text: https://academic.oup.com/aje/article-abstract/47/1/120/116918?redirected...