The therapeutic effectiveness of large doses of paludrine in acute attacks of sporozoite-induced vivax malaria, Chesson strain.

Paludrine is a new antimalarial agent which was developed in England during World War II. In an extensive investigation of the antimalarial activity of pyrimidine derivatives, Curd, Davey, and Rose (1, 2) synthesized the drug, N,-p-chlorophenyl-N,-isopropylbiguanide, in 1945 and demonstrated that it exhibited a high degree of activity in avian malaria. Maegraith, Adams and their co-workers (3, 4, 5) tested this compound in human infections and found that it was a highly effective agent in the treatment of both srvax and falciparum malaria in man. Paludrine has been studied extensively by English (5) and Australian investigators (6) and its activity and usefulness have been confirmed.

Full text article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC438889/pdf/jcinvest00390-00...