Treatment of Plasmodium vivax malaria--time for a change?

Cases of Plasmodium vivax that relapse despite conventional courses for primaquine (15mg daily for 14 days) appear to be increasing in number. One recent estimate is that 17.5% of P. vivax infection acquired in Thailand are resistant to conventional doses (Bunnag et al, 1994). We undertook a retrospective analysis of all patients with P. vivax seen at the hospital for Tropical Diseases in London, UK between January 1994 and June 1995 to assess the frequency of relapse.

Full text article: https://academic.oup.com/trstmh/article-abstract/91/1/76/1926047?redirec...